PKC beta antibody (Protein Kinase C, beta)

Details for Product anti-PRKCB Antibody No. ABIN6944656
Antigen
  • PKC-beta
  • PKCB
  • PRKCB1
  • PRKCB2
  • A130082F03Rik
  • PKC-Beta
  • Pkcb
  • Prkcb1
  • Prkcb2
  • PKC-B
  • Prkcb
  • prkcb1
  • zgc:63591
  • PKC
  • PRKCB_tv2
  • Pkc53E
  • prkcb1l
  • zgc:64063
  • protein kinase C beta
  • protein kinase C, beta
  • protein kinase C, beta b
  • protein kinase C, beta a
  • PRKCB
  • Prkcb
  • prkcbb
  • prkcba
Reactivity
Human, Mouse (Murine), Rat (Rattus)
220
178
160
18
17
14
11
3
3
2
2
2
2
1
1
1
Host
Rabbit
252
9
8
7
1
Clonality (Clone)
Monoclonal ()
Conjugate
This PKC beta antibody is un-conjugated
20
15
8
8
8
7
7
7
7
6
6
6
2
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (IHC), Western Blotting (WB)
211
112
101
22
22
17
17
14
11
7
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1
1
Options
Immunogen Human PKC beta 2 between 600 to C-terminus
Clone 10A1
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others PKC beta products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name PRKCB (PRKCB Antibody Abstract)
Background

Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function. PKCs were originally identified as serine/threonine protein kinases whose activity was dependent on calcium and phospholipids. Diacylglycerols (DAG) and tumor promoting phorbol esters bind to and activate PKC. PKCs can be subdivided into at least two major classes including conventional PKC isoforms (α, βI, βII and γ) and novel PKC isoforms. Patterns of expression for each PKC isoform differ among tissues and PKC family members exhibit clear differences in their cofactor dependencies. For instance, the kinase activities of nPKC δ and é are independent of Ca2+. On the other hand, nPKC δ and ε, as well as all of the cPKC members, possess phorbol ester-binding activities and kinase activities.


Synonyms: Protein kinase C beta type, PKC-B, PKC-beta, PRKCB, PKCB, PRKCB1
Gene ID 5579
UniProt P05771
Pathways WNT Signaling, TCR Signaling, Thyroid Hormone Synthesis, Nuclear Hormone Receptor Binding, Chromatin Binding, Myometrial Relaxation and Contraction, VEGF Signaling, Unfolded protein response
Application Notes WB(1:300-1000), FCM(1:20-100), IF(ICC)(1:50-200), IHC()
Restrictions For Research Use only
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Expiry Date 12 months
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