ACTH antibody

Catalog No. ABIN6950780

The Mouse Monoclonal anti-ACTH antibody is suitable to detect ACTH in samples from Human. It has been validated for IHC.

Quick Overview for ACTH antibody (ABIN6950780)

Target: ACTH (Adrenocorticotropic hormone (ACTH))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ACTH antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-ACTH Antibody

Purpose: Adrenocorticotropin (ACTH) mouse mAb

Specificity: The antibody can specifically recognize human ACTH protein.

Purification: The antibody was purified by affinity chromatography using a specific immunogen.

Immunogen: A synthetic peptide corresponding to the amino acid region 100 - 200 of the human Adrenocorticotropin protein.

Isotype: IgG

Application Details

Application Notes: IHC, 1:200-1:400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for ACTH

Target: ACTH (Adrenocorticotropic hormone (ACTH))

Alternative Name: ACTH-Adrenocorticotropin (ACTH)

Background:

Synonyms: ACTH, Adrenocorticotropic hormone, Adrenocorticotropin, alpha melanocyte stimulating hormone, Alpha MSH, Alpha-MSH, beta endorphin, Beta LPH, beta melanocyte stimulating hormone, Beta MSH, Beta-LPH, Beta-MSH, CLIP, Gamma MSH, Gamma-LPH, Gamma-MSH, Lipotropin beta, Lipotropin gamma, LPH, Melanotropin alpha, Melanotropin, Melanotropin beta, Melanotropin gamma, met enkephalin, MSH, NPP, POC, POMC, pro ACTH endorphin, Proopiomelanocortin, Proopiomelanocortin preproprotein

Background: ACTH is a polypeptide hormone secreted by anterior pituitary cells. ACTH effects adrenal gland to product of cortisol and it also mediates bone formation and osteoblast survival. ACTH antibody is mainly used for functional classification of pituitary tumors and differential diagnosis of primary and metastatic pituitary tumors. Studies have shown that abnormal ACTH products are often related to lung small cell carcinoma, so it can be used to detect the distribution of hormone cells in some neuroendocrine tumors, such as pheochromocytoma and carcinoid.

Gene Name: POMC

Protein Name: Adrenocorticotropin

Gene ID: 5443

UniProt: P01189

Pathways: Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity