MUC16 antibody

Catalog No. ABIN6950789

The Mouse Monoclonal anti-MUC16 antibody is suitable to detect MUC16 in samples from Human. It has been validated for IHC.

Quick Overview for MUC16 antibody (ABIN6950789)

Target: MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MUC16 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-MUC16 Antibody

Purpose: MUC16 mouse mAb

Specificity: The antibody can specifically recognize human CA-125 protein.

Purification: The antibody was purified by affinity chromatography using a specific immunogen.

Immunogen: A synthetic peptide corresponding to the amino acid region External domain of the CA - 125 molecule of the human MUC16 protein.

Isotype: IgG

Application Details

Application Notes: IHC, 1:50-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for MUC16

Target: MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))

Alternative Name: CA 125

Background:

Synonyms: CA 125, CA-125, CA125, CA125 ovarian cancer antigen, Cancer antigen 125, FLJ14303, MUC 16, MUC-16, MUC16, MUC16_HUMAN, Mucin 16, Mucin 16 cell surface associated, Mucin-16, Mucin16, Ovarian cancer related tumor marker CA125, Ovarian cancer-related tumor marker CA125, Ovarian carcinoma antigen CA125

Background: CA125 is a high molecular weight glycoprotein that plays an important role in forming a protective mucous barrier. It is mainly expressed in endometrium, cervical endometrium, fallopian tube epithelial cells and mesothelial cells. However, it is not expressed in normal non menstrual and pregnant ovarie. CA125 is an important marker of ovarian serous adenocarcinoma. It has reference value for the differential diagnosis of serous cystadenocarcinoma and mucinous cystadenocarcinoma. It is mainly used in the study of ovarian cancer and its metastasis.

Gene Name: MUC16

Protein Name: MUC16

Gene ID: 94025

UniProt: Q8WXI7