COL2 antibody

Catalog No. ABIN6950841

The Mouse Monoclonal anti-COL2 antibody is suitable to detect COL2 in samples from Human. It has been validated for IHC.

Quick Overview for COL2 antibody (ABIN6950841)

Target: COL2 (Collagen, Type II (COL2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This COL2 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-COL2 Antibody

Purpose: E-Cadherin mouse mAb

Specificity: The antibody can specifically recognize E-cadherin protein.

Purification: The antibody was purified by affinity chromatography using a specific immunogen.

Immunogen: A synthetic peptide corresponding to the amino acid region 700 - 800 of the human E - Cadherin protein.

Isotype: IgG

Application Details

Application Notes: IHC, 1:200-1:400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for COL2

Target: COL2 (Collagen, Type II (COL2))

Alternative Name: Collagen Type II

Background:

Synonyms: Cadherin-1, CAM 120/80, Epithelial cadherin (E-cadherin) , Uvomorulin, CD324, CDH1, CDHE

Background: E-Cadherein, 120 kDa, is a critical regulator of epithelial junction formation. The E-cadherin internal domain binds with alpha, beta, gamma, and p120 catenins to anchor the ECAD complex to the actin cytoskeleton of the cell. E-cadherin is expressed in virtually all epithelial cells with the exception of adrenocortical cells. The expression in liver cells is weaker than in most other epithelia. ECAD is also expressed in melanocytes (adhering to squamous epithelial cells) . Mesothelial cells and granulosa cells are ECAD negative. Mesenchymal cells and neural crest cells are mostly negative but some types may show a weak reaction. Testicular germinative cells are weakly positive. At present, it is commonly used to differentiate breast lobular cancer from ductal cancer (the former is often negative, the latter is often positive) .

Gene Name: CDH1

Protein Name: E-Cadherin

Gene ID: 999

UniProt: P12830