TGFBR1 antibody

Catalog No. ABIN6950907

The Mouse Monoclonal anti-TGFBR1 antibody (ABIN6950907) specifically detects TGFBR1 in IHC. The antibody is reactive with Human, Mouse, Rat and Cow samples.

Quick Overview for TGFBR1 antibody (ABIN6950907)

Target: TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))

Reactivity: Human, Mouse, Rat, Cow

Host: Mouse

Clonality: Monoclonal

Conjugate: This TGFBR1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-TGFBR1 Antibody

Purpose: TGF β Receptor I mouse mAb

Specificity: The antibody can specifically recognize human TGF β Receptor I protein.

Purification: The antibody was purified by affinity chromatography using a specific immunogen.

Immunogen: A synthetic peptide corresponding to the amino acid region 34 - 100 of the human TGF beta Receptor I protein.

Isotype: IgG

Application Details

Application Notes: IHC, 1:50-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for TGFBR1

Target: TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))

Alternative Name: TGF beta Receptor I

Background:

Synonyms: AAT5, ALK5, ESS1, LDS1, MSSE, SKR4, TBRI, ALK-5, LDS1A, LDS2A, TBR-i, TGFR-1, ACVRLK4, tbetaR-I, TGF beta Receptor I (TGFBR1)

Background: Members of the transforming growth factor β (TGF-β) superfamily are key regulators of cell proliferation, differentiation, development, morphogenesis, and disease pathogenesis. TGF-β signals through three cell surface receptors: type I (RI), type II (RII), and type III (RIII). Type I and type II receptors are serine/threonine kinases that form heteromeric complexes. Upon ligand binding, type II receptors form a stable complex with type I receptors, leading to phosphorylation and activation of the type I receptor kinase.

Gene Name: TGFBR1 ALK5 SKR4

Protein Name: TGF β Receptor I

Gene ID: 7046

UniProt: P36897

Pathways: Growth Factor Binding