CBFB antibody

Catalog No. ABIN6952396

The Rabbit Polyclonal anti-CBFB antibody (ABIN6952396) specifically detects CBFB in ELISA, ChIP and ChIP-seq. The antibody is reactive with Human samples.

Quick Overview for CBFB antibody (ABIN6952396)

Target: CBFB (Core-Binding Factor, beta Subunit (CBFB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBFB antibody is un-conjugated

Application: ELISA, Chromatin Immunoprecipitation (ChIP), ChIP DNA-Sequencing (ChIP-seq)

Product Details anti-CBFB Antibody

Specificity: Polyclonal antibody raised in rabbit against human CBFb (core-binding factor, beta subunit) using two KLH-conjugated synthetic peptides containing sequences from the central region of the protein.

Purification: whole antiserum

Immunogen: synthetic peptide

Application Details

Application Notes: ChIP 4 μL:ChIP
ELISA 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: serum, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for CBFB

Target: CBFB (Core-Binding Factor, beta Subunit (CBFB))

Alternative Name: CBFb

Background: CBFb (UniProtKB/Swiss-Prot entry Q13951) represents the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family. These transcription factors regulate a host of genes specific to haematopoiesis (e.g. RUNX1) and osteogenesis (e.g. RUNX2). The beta subunit is the regulatory subunit which allosterically enhances the activity of the DNA binding alpha subunit as the complex binds to the core site of various enhancers and promoters. CBFb can be involved in a chromosomal rearrangement of chromosome 16 (inv(16)(p13q22)) which produces a fusion protein consisting of the N terminus of CBFb and the C-terminal portion of MYH11. This chromosomal rearrangement is associated with acute myeloid leukaemia of the M4Eo subtype

UniProt: Q13951

Pathways: Regulation of Lipid Metabolism by PPARalpha