KDM5C antibody

Catalog No. ABIN6952407

The Rabbit Polyclonal anti-KDM5C antibody is suitable to detect KDM5C in samples from Human. It has been validated for WB, IP, ChIP and ChIP-seq.

Quick Overview for KDM5C antibody (ABIN6952407)

Target: KDM5C (Lysine (K)-Specific Demethylase 5C (KDM5C))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KDM5C antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Chromatin Immunoprecipitation (ChIP), ChIP DNA-Sequencing (ChIP-seq)

Product Details anti-KDM5C Antibody

Specificity: Polyclonal antibody raised in rabbit against human JARID1C (Jumonji, AT Rich Interactive Domain 1C), using a synthetic peptide containing a sequence from the central part of the protein

Cross-Reactivity: Mouse (Murine)

Purification: Affinity purified

Immunogen: synthetic peptide

Application Details

Application Notes: ChIP/ChIP-seq 5 μg:ChIP
WB 1:1,000
IP 6 μg:IP

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 μg/μL

Buffer: TBS, 0,1 % BSA, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for KDM5C

Target: KDM5C (Lysine (K)-Specific Demethylase 5C (KDM5C))

Alternative Name: JARID1C

Background: JARID1C (UniProtKB/Swiss-Prot entry P41229) is a histone demethylase that specifically demethylates tri- and dimethylated Lys-4 of histone H3. It has no activity towards monomethylated H3K4, H3K9, H3K27, H3K36, H3K79 or H4K20. It is involved in transcriptional regulation and chromatin remodeling. JARID1C participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Mutations in JARID1C have been associated with X-linked mental retardation

UniProt: P41229

Pathways: Warburg Effect