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IL7R antibody (PE-Cy7)

IL7R Reactivity: Mouse FACS Host: Rat Monoclonal A7R34 PE-Cy7
Catalog No. ABIN7278425
  • Target See all IL7R Antibodies
    IL7R (Interleukin 7 Receptor (IL7R))
    Reactivity
    • 110
    • 49
    • 26
    • 7
    • 4
    • 2
    • 1
    Mouse
    Host
    • 81
    • 36
    • 27
    • 1
    • 1
    Rat
    Clonality
    • 81
    • 63
    • 2
    Monoclonal
    Conjugate
    • 63
    • 11
    • 10
    • 8
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IL7R antibody is conjugated to PE-Cy7
    Application
    • 84
    • 77
    • 45
    • 26
    • 26
    • 13
    • 13
    • 9
    • 8
    • 8
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Purification
    This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation. It is recommended to store the product undiluted at 4°C, and protected from prolonged exposure to light. Do not freeze.
    Clone
    A7R34
    Isotype
    IgG2a kappa
    Top Product
    Discover our top product IL7R Primary Antibody
  • Application Notes
    This antibody preparation has been quality-tested for flow cytometry using mouse spleen cells, or an appropriate cell type (where indi- cated). The amount of antibody required for optimal staining of a cell sample should be determined empirically in your system.
    Comment

    0.2 mg/mL

    Restrictions
    For Research Use only
  • Buffer
    10 mM NaH2PO4, 150 mM NaCl, 0.09 % Sodium azide, 0.1 % gelatin, pH 7.2
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    2-8°C protected from light
    Expiry Date
    12 months
  • Target
    IL7R (Interleukin 7 Receptor (IL7R))
    Alternative Name
    CD127 (IL-7Ra) (IL7R Products)
    Synonyms
    IL7R antibody, CD127 antibody, IL-7Ralpha antibody, CDW127 antibody, IL-7R-alpha antibody, IL7RA antibody, ILRA antibody, IL-7RA antibody, interleukin 7 receptor antibody, IL7R antibody, Il7r antibody
    Background
    The A7R34 antibody is specific for mouse CD127, a 60-90 kDa cell surface protein also known as the Interleukin-7 Receptor alpha chain, or IL-7R alpha. CD127 is typically expressed at the cell surface as a heterodimer with the common gamma chain (CD132). This complex acts as the functional receptor for IL-7, a cytokine important in T and B cell development, and in mature T cell homeostasis. A second cytokine known as Thymic Stromal Lymphopoietin (TSLP) also binds to a receptor complex of CD127 and the TSLPR chain to trigger activation of dendritic cells, and is involved in B cell development, allergy and autoimmunity.The A7R34 antibody may be used as a phenotypic marker for CD127 on immature B cells, on subsets of thymocytes which are double negative (CD4-CD8- ) or single positive (CD4+ or CD8+), and at low levels on mature, peripheral T cells. CD127 is a key marker, when used in combination with CD4 and CD25, to distinguish Treg and effector/memory Treg populations known as T(REM).
    Gene ID
    16172
    UniProt
    P16872
    Pathways
    JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Regulation of Cell Size
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