IFNA2 antibody (Biotin)

Catalog No. ABIN6963844

Cited in 5+ publications. The Biotin-conjugated Mouse Monoclonal anti-IFNA2 antibody (Clone MT2) (ABIN6963844) specifically detects IFNA2 in ELISA and ELISpot. The antibody is reactive with Human samples.

Quick Overview for IFNA2 antibody (Biotin) (ABIN6963844)

Target: IFNA2 (Interferon, alpha 2 (IFNA2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IFNA2 antibody is conjugated to Biotin

Application: ELISA, ELISpot

Clone: MT2

Product Details anti-IFNA2 Antibody (Biotin)

Specificity: Native and recombinant human IFN-α subtypes 2a, 2b, 2c

Purification: Biotinylated through reaction with a N-hydroxysuccinimide ester of biotin.,Purified from in vitro cultures by protein G affinity chromatography.

Sterility: 0.2 μm filtered

Immunogen: Recombinant human IFN-alpha 2c

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: supplied at 1 mg/mL in PBS with 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store product at 4-8°C or frozen at -20°C or below. Avoid repeated freezing/ thawing.

Expiry Date: 18 months

References for anti-IFNA2 antibody (Biotin) (ABIN6963844)

Yadav, McLeod, Nowell, Selby, Johnston, Kaminskas, Trevaskis: "Distribution of therapeutic proteins into thoracic lymph after intravenous administration is protein size-dependent and primarily occurs within the liver and mesentery." in: Journal of controlled release : official journal of the Controlled Release Society, Vol. 272, pp. 17-28, (2019) (PubMed).

Hochmann, Mittermeir, Santic, Koszik, Griessner, Sonderegger, Hoffmann, Russe, Scheiblhofer, Weiss, Mandler, Schneeberger, Strunk: "Evaluation of modified Interferon alpha mRNA constructs for the treatment of non-melanoma skin cancer." in: Scientific reports, Vol. 8, Issue 1, pp. 12954, (2019) (PubMed).

Chan, Feeney, Leong, McLeod, Porter, Williams, Kaminskas: "An Evaluation of Optimal PEGylation Strategies for Maximizing the Lymphatic Exposure and Antiviral Activity of Interferon after Subcutaneous Administration." in: Biomacromolecules, Vol. 18, Issue 9, pp. 2866-2875, (2018) (PubMed).

Bijak, Dziedzic, Synowiec, Sliwinski, Saluk-Bijak: "Flavonolignans Inhibit IL1-β-Induced Cross-Talk between Blood Platelets and Leukocytes." in: Nutrients, Vol. 9, Issue 9, (2018) (PubMed).

Ingelsson, Söderberg, Strid, Söderberg, Bergh, Loitto, Lotfi, Segelmark, Spyrou, Rosén: "Lymphocytes eject interferogenic mitochondrial DNA webs in response to CpG and non-CpG oligodeoxynucleotides of class C." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, Issue 3, pp. E478-E487, (2018) (PubMed).

Target Details for IFNA2

Target: IFNA2 (Interferon, alpha 2 (IFNA2))

Alternative Name: IFNA2

Gene ID: 3440

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Hepatitis C