NEUROD1 antibody (pSer274) (AbBy Fluor® 488)

Catalog No. ABIN6977662

This Rabbit Polyclonal antibody specifically detects NEUROD1 in WB, IF (cc) and IF (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for NEUROD1 antibody (pSer274) (AbBy Fluor® 488) (ABIN6977662)

Target: NEUROD1 (Neuronal Differentiation 1 (NEUROD1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NEUROD1 antibody is conjugated to AbBy Fluor® 488

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-NEUROD1 Antibody (AbBy Fluor® 488)

Binding Specificity: pSer274

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Cow,Sheep,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthesized phosphopeptide derived from human NeuroD1 around the phosphorylation site of Serine 274

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for NEUROD1

Target: NEUROD1 (Neuronal Differentiation 1 (NEUROD1))

Alternative Name: NeuroD1

Background:

Synonyms: NeuroD1 (phospho S274), p-NeuroD1 (phospho S274), atonal, basic helix loop helix transcription factor, BETA 2, Beta cell E box transactivator 2, BETA2, BHF 1, BHF1, bHLHa3, class A basic helix loop helix protein 3, Class A basic helix-loop-helix protein 3, MODY 6, MODY6, NDF1_HUMAN, NEUROD, NeuroD1, Neurogenic differentiation 1, Neurogenic differentiation factor 1, neurogenic helix loop helix protein NEUROD, NIDDM.

Background: This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus.

Gene ID: 4760

UniProt: Q13562

Pathways: Dopaminergic Neurogenesis, Hormone Transport, Carbohydrate Homeostasis