PAX6 antibody (AA 221-320) (AbBy Fluor® 488)

Catalog No. ABIN6977909

The Rabbit Polyclonal anti-PAX6 antibody has been validated for WB, IF (p) and IF (cc). It is suitable to detect PAX6 in samples from Mouse and Rat.

Quick Overview for PAX6 antibody (AA 221-320) (AbBy Fluor® 488) (ABIN6977909)

Target: PAX6 (Paired Box 6 (PAX6))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAX6 antibody is conjugated to AbBy Fluor® 488

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Product Details anti-PAX6 Antibody (AbBy Fluor® 488)

Binding Specificity: AA 221-320

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Sheep,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PAX6

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for PAX6

Target: PAX6 (Paired Box 6 (PAX6))

Alternative Name: PAX6

Background:

Synonyms: AN 2, AN antibody, AN2, Aniridia type II protein, D11S812E, MGC17209, MGDA, Oculorhombin, Paired box 6, Paired box gene 6 (aniridia keratitis), Paired Box Gene 6, Paired box homeotic gene 6, Paired box protein Pax-6, Paired box protein Pax6, PAX 6, PAX6, PAX6_HUMAN, Sey, WAGR.

Background: Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.

Gene ID: 5080

UniProt: P26367

Pathways: Peptide Hormone Metabolism, Carbohydrate Homeostasis