C5 antibody (AA 51-150) (AbBy Fluor® 555)

Catalog No. ABIN6978118

This Rabbit Polyclonal antibody specifically detects C5 in IF (p) and IF (cc). It exhibits reactivity toward Human.

Quick Overview for C5 antibody (AA 51-150) (AbBy Fluor® 555) (ABIN6978118)

Target: C5 (Complement Component 5 (C5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C5 antibody is conjugated to AbBy Fluor® 555

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Product Details anti-C5 Antibody (AbBy Fluor® 555)

Binding Specificity: AA 51-150

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Complement C5 beta chain

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for C5

Target: C5 (Complement Component 5 (C5))

Alternative Name: Complement C5 beta chain

Background:

Synonyms: Anaphylatoxin C5a, C5, Complement C5, Complement C5 precursor, Complement component 5, CPAMD4, CO5_HUMAN.

Background: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.
Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).

Gene ID: 727

UniProt: P01031

Pathways: Complement System, Carbohydrate Homeostasis