ERO1LB antibody (AA 1-100) (Cy3)

Catalog No. ABIN6983361

This anti-ERO1LB antibody is a Rabbit Polyclonal antibody detecting ERO1LB in WB, IF (cc) and IF (p). Suitable for Mouse and Rat.

Quick Overview for ERO1LB antibody (AA 1-100) (Cy3) (ABIN6983361)

Target: ERO1LB (ERO1-Like beta (ERO1LB))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERO1LB antibody is conjugated to Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-ERO1LB Antibody (Cy3)

Binding Specificity: AA 1-100

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Pig,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ERO1LB

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ERO1LB

Target: ERO1LB (ERO1-Like beta (ERO1LB))

Alternative Name: ERO1LB

Background:

Synonyms: Endoplasmic oxidoreductin-1-like protein B, ERO1-L-beta, ERO1B, ERO1-like protein beta, Oxidoreductin-1-L-beta

Background: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50 % of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10 %). Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis.

Gene ID: 56605

UniProt: Q86YB8

Pathways: SARS-CoV-2 Protein Interactome