ERO1LB antibody (AA 101-400) (Biotin)

Catalog No. ABIN7152005

Product Details anti-ERO1LB Antibody (Biotin)

Target: ERO1LB (ERO1-Like beta (ERO1LB))

Binding Specificity: AA 101-400

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERO1LB antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human ERO1-like protein beta protein (101-400AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ERO1LB

Target: ERO1LB (ERO1-Like beta (ERO1LB))

Alternative Name: ERO1B (ERO1LB Products)

Synonyms: RGD1563548 antibody, 1300013B24Rik antibody, 1700065B09Rik antibody, AI447560 antibody, ero1-beta antibody, endoplasmic reticulum oxidoreductase 1 beta antibody, ERO1-like beta (S. cerevisiae) antibody, Ero1b antibody, ERO1B antibody, Ero1lb antibody

Background:

Background: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50 % of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10 %). Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis.

Aliases: Endoplasmic oxidoreductin-1-like protein B antibody, Endoplasmic reticulum oxidoreductin-1-like protein B antibody, ERO1, S. cerevisiae, homolog of, beta antibody, ERO1-L-beta antibody, ERO1-like beta (S. cerevisiae) antibody, ERO1-like protein beta antibody, ERO1B_HUMAN antibody, Ero1lb antibody, Oxidoreductin-1-L-beta antibody

UniProt: Q86YB8

Pathways: SARS-CoV-2 Protein Interactome