SOCS6 antibody (AA 21-120) (Cy5.5)

Catalog No. ABIN6984945

This anti-SOCS6 antibody is a Rabbit Polyclonal antibody detecting SOCS6 in WB, IF (cc) and IF (p). Suitable for Mouse and Chicken.

Quick Overview for SOCS6 antibody (AA 21-120) (Cy5.5) (ABIN6984945)

Target: SOCS6 (Suppressor of Cytokine Signaling 6 (SOCS6))

Reactivity: Mouse, Chicken

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS6 antibody is conjugated to Cy5.5

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-SOCS6 Antibody (Cy5.5)

Binding Specificity: AA 21-120

Cross-Reactivity: Chicken, Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SOCS6

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for SOCS6

Target: SOCS6 (Suppressor of Cytokine Signaling 6 (SOCS6))

Alternative Name: SOCS6

Background:

Synonyms: CIS-4, CIS4, Cish4, Cytokine inducible SH2 protein 4, Cytokine-inducible SH2 protein 4, HSPC060, SOCS-4, SOCS-6, SOCS4, Socs6, SOCS6_HUMAN, SSI4, STAI4, STAT induced STAT inhibitor 4, STAT4, STATI4, Suppressor of cytokine signaling 4, Suppressor of cytokine signaling 6.

Background: The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008].

Gene ID: 9306

UniProt: O14544

Pathways: JAK-STAT Signaling, Carbohydrate Homeostasis