Metabotropic Glutamate Receptor 5 antibody (AA 431-530) (Cy5.5)

Catalog No. ABIN6985301

The Rabbit Polyclonal anti-Metabotropic Glutamate Receptor 5 antibody has been validated for WB and FACS. It is suitable to detect Metabotropic Glutamate Receptor 5 in samples from Rat and Mouse.

Quick Overview for Metabotropic Glutamate Receptor 5 antibody (AA 431-530) (Cy5.5) (ABIN6985301)

Target: Metabotropic Glutamate Receptor 5 (GRM5) (Glutamate Receptor, Metabotropic 5 (GRM5))

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Metabotropic Glutamate Receptor 5 antibody is conjugated to Cy5.5

Application: Western Blotting (WB), Flow Cytometry (FACS)

Product Details anti-Metabotropic Glutamate Receptor 5 Antibody (Cy5.5)

Binding Specificity: AA 431-530

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Cow,Sheep,Horse,Chicken,Monkey

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MGLUR5

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Metabotropic Glutamate Receptor 5

Target: Metabotropic Glutamate Receptor 5 (GRM5) (Glutamate Receptor, Metabotropic 5 (GRM5))

Alternative Name: MGLUR5

Background:

Synonyms: MGLUR5B, Glutamate receptor metabotropic 5, GPRC1E, GRM 5, GRM5, Metabotropic glutamate receptor 5, mGlu5, mGluR5, mGluR5a, mGluR5b, Metabotropic glutamate receptor 5 variant F, Metabotropic Glutamate Receptor 5b, Metabotropic glutamate receptor 5 variant G, Metabotropic glutamate receptor 5 variant H, PPP1R86, GRM5_HUMAN,

Background: Glutamate receptors constitute the principal excitatory neurotransmitter receptors in brain. Two classes of glutamate receptors exist: Ionotropic receptors, and metabotropic receptors (mGluRs). Metabotropic Glutamate Receptor 5b (GRM5) activity is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. The metabotropic glutamate receptor type 5 (mGlu5) is expressed in two splice variants, mGlu5a and mGlu5b, which differ in that mGlu5b has a 33-amino acid insert in the intracellular C-terminal domain. This receptor subtype is highly regulated, with higher levels found in developing animals.

Gene ID: 2915

UniProt: P41594

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity