THRB antibody (AA 201-300) (PE)

Catalog No. ABIN6988259

The Rabbit Polyclonal anti-THRB antibody has been validated for WB and FACS. It is suitable to detect THRB in samples from Human, Mouse and Rat.

Quick Overview for THRB antibody (AA 201-300) (PE) (ABIN6988259)

Target: THRB (Thyroid Hormone Receptor, beta (THRB))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This THRB antibody is conjugated to PE

Application: Western Blotting (WB), Flow Cytometry (FACS)

Product Details anti-THRB Antibody (PE)

Binding Specificity: AA 201-300

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Cow,Sheep,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Thyroid Hormone Receptor beta

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for THRB

Target: THRB (Thyroid Hormone Receptor, beta (THRB))

Alternative Name: THRB

Background:

Synonyms: Thyroid Hormone Receptor beta, Avian erythroblastic leukemia viral v erb a oncogene homolog 2, C ERBA 2, C ERBA BETA, c-erbA-2, c-erbA-beta, ERBA 2, ERBA BETA, ERBA2, Erythroblastic leukemia viral v erb a oncogene homolog 2 avian, generalized resistance to thyroid hormone, GRTH, MGC126109, MGC126110, NR1A2, Nuclear receptor subfamily 1 group A member 2, Oncogene ERBA2, PRTH, THB_HUMAN, THR 1, THR1, THRB 1,

Background: Thyroid hormone receptors (TRs) are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3). Thyroid hormone receptor b2 (TRb2) is a high affinity receptor for triiodothyronine which belongs to the nuclear hormone receptor family and the NR1 subfamily. It is composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain. Defects in the receptor result in generalized thyroid hormone resistance (GTHR). GTHR is transmitted as an autosomal dominant trait, but an autosomal recessive form also exists. The disease is characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone.

Gene ID: 7068

UniProt: P10828

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound