FANCD2 antibody (pSer1404) (PE)

Catalog No. ABIN6988326

The PE-conjugated Rabbit Polyclonal anti-FANCD2 antibody (ABIN6988326) specifically detects FANCD2 in FACS. The antibody is reactive with Human samples.

Quick Overview for FANCD2 antibody (pSer1404) (PE) (ABIN6988326)

Target: FANCD2 (Fanconi Anemia, Complementation Group D2 (FANCD2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FANCD2 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-FANCD2 Antibody (PE)

Binding Specificity: pSer1404

Cross-Reactivity: Human

Predicted Reactivity: Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human FANCD2 around the phosphorylation site of Ser1404

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for FANCD2

Target: FANCD2 (Fanconi Anemia, Complementation Group D2 (FANCD2))

Alternative Name: FANCD2

Background:

Synonyms: FANCD2 phospho S1404, FANCD2 phospho Ser1404, p-FANCD2 phospho S1404, FA 4, FA D2, FA4, FAC D2, FACD 2, FACD, FACD2, FAD, FAD2, FANC D2, FANCD 2, FANCD, Protein FACD2, Type 4 Fanconi pancytopenia, FACD2_HUMAN, Fanconi anemia group D2 protein, Protein FACD2.

Background: Fanconi Anemia (FANC) is a human autosomal-recessive cancer susceptibility disorder characterized by congenital defects, progressive bone marrow failure, and cellular hypersensitivity to mitomycin C (MMC). The FANC subunit D2 protein is vital for cellular resistance to DNA cross-linking and the arrest of DNA synthesis after ionizing radiation. DNA damage activates the monoubiquitination of FANC D2, targeting nuclear foci containing the BRCA 1 protein.

Gene ID: 2177

Pathways: DNA Damage Repair