PKD1 antibody (AA 131-230) (PE)

Catalog No. ABIN6988526

The Rabbit Polyclonal anti-PKD1 antibody is suitable to detect PKD1 in samples from Human and Mouse. It has been validated for WB and FACS.

Quick Overview for PKD1 antibody (AA 131-230) (PE) (ABIN6988526)

Target: PKD1 (Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PKD1 antibody is conjugated to PE

Application: Western Blotting (WB), Flow Cytometry (FACS)

Product Details anti-PKD1 Antibody (PE)

Binding Specificity: AA 131-230

Cross-Reactivity: Human, Mouse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Polycystin 1

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for PKD1

Target: PKD1 (Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))

Alternative Name: Polycystin 1

Background:

Synonyms: PBP, Pc-1, TRPP1, Polycystin-1, Autosomal dominant polycystic kidney disease 1 protein, PKD1

Background: Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.

Gene ID: 5310

UniProt: P98161

Pathways: Myometrial Relaxation and Contraction, Maintenance of Protein Location