FERMT1 antibody (AA 216-677)

Catalog No. ABIN7863280

This Mouse Monoclonal antibody specifically detects FERMT1 in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for FERMT1 antibody (AA 216-677) (ABIN7863280)

Target: FERMT1 (Fermitin Family Member 1 (FERMT1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FERMT1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 4A5-14

Product Details anti-FERMT1 Antibody

Binding Specificity: AA 216-677

Purpose: Kindlin-1 / KIND1 Antibody

Specificity: Kindlin-1 (also known as KIND1, KINDLERIN, UNC112-RELATED PROTEIN 1 (URP1) is an important component of cell-extracellular matrix adhesion. Kindlin-1 is involved in cell adhesion, possibly via its interaction with integrins and may mediate TGF-beta 1 signaling during tumor progression. Kindlin-1 has been shown to be significantly upregulated in lung and colon carcinomas. Mutations in the kindlin-1 gene, FERMT1, causes Kindler syndrome. Kindler syndrome is an autosomal recessive disorder characterized by neonatal blistering, sun sensitivity, atrophy, abnormal pigmentation and fragility of the skin. We have developed monoclonal anti-kidlin-1 antibodies. This monoclonal antibody recognizes kindlin-1 in multiple assays including Western blotting, immunoprecipitation, immunohistochemical and immunofluorescent staining.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant protein containing Kindlin-1 (residues 216-677)

Isotype: IgG2a, lambda

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for FERMT1

Target: FERMT1 (Fermitin Family Member 1 (FERMT1))

Alternative Name: Kindlin-1

Background:

Fermitin family homolog 1 (Fermt1), Kindlin-1 (KIND1), Kindlerin, Unc-112, UNC112A, URP1, DTGCU2

293T whole cell lysate. Human tonsil or liver.

Molecular Weight: 77kDa

Gene ID: 55612, 472054

UniProt: Q9BQL6