Cytokeratin 18 antibody

Catalog No. ABIN6989433

The Mouse Monoclonal anti-Cytokeratin 18 antibody (Clone 4H7) (ABIN6989433) specifically detects Cytokeratin 18 in WB, IF and ICC. The antibody is reactive with Human samples.

Quick Overview for Cytokeratin 18 antibody (ABIN6989433)

Target: Cytokeratin 18 (KRT18) (Keratin 18 (KRT18))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cytokeratin 18 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: 4H7

Product Details anti-Cytokeratin 18 Antibody

Purpose: CK18 Monoclonal Antibody

Cross-Reactivity: Human, Mouse

Purification: Purified by Protein G.

Immunogen: KLH conjugated synthetic peptide derived from human CK18

Isotype: IgG

Application Details

Application Notes: WB(WB=1:500-1000), ICC/IF(ICC/IF=1:100)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for Cytokeratin 18

Target: Cytokeratin 18 (KRT18) (Keratin 18 (KRT18))

Alternative Name: CK18

Background:

Synonyms: Cell proliferation inducing gene 46 protein, Cell proliferation inducing protein 46, CK 18, CK18, CYK18, Cytokeratin 18, Cytokeratin endo B, Cytokeratin18, Keratin 18, Keratin D, Keratin type I cytoskeletal 18, Kerd, KRT18.

Background: When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.

Gene ID: 3875

UniProt: P05783

Pathways: Apoptosis, Caspase Cascade in Apoptosis