MICU1 antibody (AA 1-250)

Catalog No. ABIN6989439

This anti-MICU1 antibody is a Mouse Monoclonal antibody detecting MICU1 in WB. Suitable for Human, Rat and Mouse.

Quick Overview for MICU1 antibody (AA 1-250) (ABIN6989439)

Target: MICU1 (Mitochondrial Calcium Uptake 1 (MICU1))

Reactivity: Human, Rat, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This MICU1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 1H8

Product Details anti-MICU1 Antibody

Binding Specificity: AA 1-250

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein G.

Immunogen: Recombinant human CBARA1 Protein (1-250/476)

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for MICU1

Target: MICU1 (Mitochondrial Calcium Uptake 1 (MICU1))

Alternative Name: CBARA1/MICU1

Background:

Synonyms: Mitochondrial Calcium Uptake 1, Calcium-Binding Atopy-Related Autoantigen 1, Atopy-Related Autoantigen CALC, Ara CALC, CBARA1, CALC, Calcium Binding Atopy-Related Autoantigen 1, Calcium Uptake Protein 1, Mitochondrial, Allergen Hom S 4, EFHA3, MPXPS, MICU1_HUMAN,

Background: Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733).

Gene ID: 10367

UniProt: Q9BPX6