NCR1 antibody (AA 1-100)

Catalog No. ABIN6989555

The Rabbit Polyclonal anti-NCR1 antibody is suitable to detect NCR1 in samples from Human. It has been validated for IF (p), IF (cc), IHC (p) and IHC (fro).

Quick Overview for NCR1 antibody (AA 1-100) (ABIN6989555)

Target: NCR1 (Natural Cytotoxicity Triggering Receptor 1 (NCR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCR1 antibody is un-conjugated

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-NCR1 Antibody

Binding Specificity: AA 1-100

Purpose: NCR1 Polyclonal Antibody

Cross-Reactivity: Human, Mouse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NCR1

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for NCR1

Target: NCR1 (Natural Cytotoxicity Triggering Receptor 1 (NCR1))

Alternative Name: NCR1

Background:

Synonyms: Natural killer cell p46-related protein, Natural cytotoxicity triggering receptor 1, NK-p46, NKp46, NK cell-activating receptor, Lymphocyte antigen 94 homolog, CD335, CD 335, LY94, NCTR1_HUMAN.

Background: The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. NCR1 is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 amino acid residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. NCR1 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. NCR1 has been implicated in NK cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines.

Gene ID: 9437

UniProt: O76036

Pathways: Regulation of Leukocyte Mediated Immunity