JAK2 antibody (pTyr1007, pTyr1008)

Catalog No. ABIN6989925

This anti-JAK2 antibody is a Rabbit Monoclonal antibody detecting JAK2 in WB, IHC, IP, IF (cc) and IHC (p). Suitable for Human, Rat and Mouse.

Quick Overview for JAK2 antibody (pTyr1007, pTyr1008) (ABIN6989925)

Target: JAK2 (Janus Kinase 2 (JAK2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This JAK2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 3G6

Product Details anti-JAK2 Antibody

Binding Specificity: pTyr1007, pTyr1008

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: Synthetic phospho-Peptide corresponding to residues surrounding Tyr1007 and 1008 of human JAK2.

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200
IP(1-2 μg)
IHC()

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for JAK2

Target: JAK2 (Janus Kinase 2 (JAK2))

Alternative Name: JAK2

Background:

Synonyms: JAK 2 antibody, JAK-2 antibody, JAK2 antibody, JAK2_HUMAN antibody, Janus Activating Kinase 2 antibody, Janus kinase 2 (a protein tyrosine kinase) antibody, Janus kinase 2 antibody, JTK 10 antibody, JTK10 antibody, kinase Jak2 antibody, OTTHUMP00000043260 antibody, THCYT3 antibody, Tyrosine protein kinase JAK2 antibody, Tyrosine-protein kinase JAK2 antibody

Background: This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008]

Gene ID: 3717

UniProt: O60674

Pathways: JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling, Unfolded Protein Response