ARNT antibody

Catalog No. ABIN6989933

The Rabbit Monoclonal anti-ARNT antibody is suitable to detect ARNT in samples from Human. It has been validated for WB, IHC and IHC (p).

Quick Overview for ARNT antibody (ABIN6989933)

Target: ARNT (Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ARNT antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 11H1

Product Details anti-ARNT Antibody

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: Recombinant protein

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC()

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for ARNT

Target: ARNT (Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT))

Alternative Name: HIF-1 beta

Background:

Synonyms: arnT antibody, ARNT protein antibody, ARNT_HUMAN antibody, Aryl hydrocarbon receptor nuclear translocator antibody, bHLHe2 antibody, Class E basic helix-loop-helix protein 2 antibody, Dioxin receptor antibody, Dioxin receptor nuclear translocator antibody, Drnt antibody, HIF 1 beta antibody, HIF 1beta antibody, HIF-1-beta antibody, HIF1-beta antibody, HIF1B antibody, HIF1beta antibody, Hypoxia Inducible Factor 1 antibody, Hypoxia inducible factor 1 beta antibody, Hypoxia-inducible factor 1-beta antibody, nuclear translocator antibody, Tango antibody

Background: This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Gene ID: 405

UniProt: P27540

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Carbohydrate Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Warburg Effect