MAP3K14 antibody (C-Term)

Catalog No. ABIN6990248

The Rabbit Polyclonal anti-MAP3K14 antibody is suitable to detect MAP3K14 in samples from Human. It has been validated for WB, ELISA, IF and ICC.

Quick Overview for MAP3K14 antibody (C-Term) (ABIN6990248)

Target: MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP3K14 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-MAP3K14 Antibody

Binding Specificity: C-Term

Purification: NIK Antibody is affinity chromatography purified via peptide column.

Immunogen: NIK antibody was raised against a 17 amino acid peptide near the carboxy terminus of human NIK. The immunogen is located within the last 50 amino acids of NIK.

Isotype: IgG

Application Details

Application Notes: NIK antibody can be used for detection of NIK by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: NIK Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: NIK antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for MAP3K14

Target: MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14))

Alternative Name: NIK

Background: NIK Antibody: Nuclear factor kappa B (NF-κ,B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κ,B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFα, LPS and mitogens. A serine/threonine protein kinase which mediates NF-κ,B activation by IL-1, TNFα, and CD95 was identified recently and designated NIK (for NF-κ,B inducing kinase). NIK is an activator of Iκ,B kinase alpha and beta (IKKα, and IKKβ,). Therefore, NIK is a key molecule in the NF-κ,B signaling pathway leading to the induction of a variety of gene expression in response to proinflammatory cytokines and bacteria products.

Molecular Weight: Predicted: 104 kDa

Gene ID: 9020

UniProt: Q99558

Pathways: NF-kappaB Signaling, TCR Signaling