GFRA3 antibody

Catalog No. ABIN6990252

Product Details anti-GFRA3 Antibody

Target: GFRA3 (GDNF Family Receptor alpha 3 (GFRA3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GFRA3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: GFR alpha 3 Antibody is Antibody is DEAE purified.

Immunogen: GFR alpha 3 antibody was raised against a 14 amino acid peptide near the center of murine GFR alpha 3. The immunogen is located within the last 50 amino acids of GFR alpha 3.

Isotype: IgG

Application Details

Application Notes: GFR alpha 3 antibody can be used for detection of GFR alpha 3 expression by Western blot at 0.5 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 5 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: GFR alpha 3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: GFR alpha 3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for GFRA3

Target: GFRA3 (GDNF Family Receptor alpha 3 (GFRA3))

Alternative Name: GFR alpha 3 (GFRA3 Products)

Synonyms: GFRA3 antibody, GFRalpha3 antibody, Y15110 antibody, GDNF family receptor alpha 3 antibody, glial cell line derived neurotrophic factor family receptor alpha 3 antibody, Gfra3 antibody, GFRA3 antibody

Background: GFR alpha 3 Antibody: Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN) play essential roles in the control of vertebrate neuron survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphadidylinositol linked protein GFRα, and Ret receptor tyrosine kinase GFRbeta. Following the findings of GFRα,-1 and -2, a novel receptor in GFRα, family was identified from human and mouse and designated GFRα,-3. GFRα,-3 binds persephin, thus, persephin, GFRα,-3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function.

Molecular Weight: Predicted: 44 kDa

Observed: 43 kDa

Gene ID: 14587

NCBI Accession: NP_034410

UniProt: O35118