IL1RAP antibody (C-Term)

Catalog No. ABIN6990297

The Rabbit Polyclonal anti-IL1RAP antibody (ABIN6990297) specifically detects IL1RAP in WB, ELISA, ICC and IF. The antibody is reactive with Human samples.

Quick Overview for IL1RAP antibody (C-Term) (ABIN6990297)

Target: IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL1RAP antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Product Details anti-IL1RAP Antibody

Binding Specificity: C-Term

Specificity: This polyclonal antibody has no cross activity to other members in the IL-1 receptor family.

Purification: IL-1RAcP Antibody is affinity chromatography purified via peptide column.

Immunogen: IL-1RAcP antibody was raised against a 16 amino acid peptide near the carboxy terminus of human IL-1RAcP. The immunogen is located within the last 50 amino acids of IL-1RAcP.

Isotype: IgG

Application Details

Application Notes: IL-1RAcP antibody can be used for detection of IL-1RAcP by Western blot at 1 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 2 μ,g/mL. For immunofluorescence start at 5 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: IL-1RAcP Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: IL-1RAcP antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for IL1RAP

Target: IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))

Alternative Name: IL-1RAcP

Background: IL-1RAcP Antibody: The pro-inflammatory cytokine IL-1 induced cellular response requires two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1RAcP forms a complex with IL-1RI in response to IL-1 treatment. The IL-1 receptor-associated kinase (IRAK), which mediates activation of NF-κ,B inducing kinae (NIK) and of NF-κ,B, recruits to the IL-1R complex through IL-1RAcP. IL-1 activation of stress-activated protein kinase and of acid sphingomyelinase also requires IL-1RAcP. Like IL-1RI, IL-1RAcP subunit is essential for IL-1 mediated cellular response. IL-1RAcP is expressed in many tissues.

Molecular Weight: Predicted: 63 kDa

Observed: 66 kDa

Gene ID: 3556

NCBI Accession: NP_001161401

UniProt: Q9NPH3

Pathways: NF-kappaB Signaling, Growth Factor Binding