BACE2 antibody (N-Term)

Catalog No. ABIN6990328

This Rabbit Polyclonal antibody specifically detects BACE2 in WB, ELISA and IHC (p). It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for BACE2 antibody (N-Term) (ABIN6990328)

Target: BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BACE2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-BACE2 Antibody

Binding Specificity: AA 30-80, N-Term

Purification: BACE2 Antibody is affinity chromatography purified via peptide column.

Immunogen: BACE2 antibody was raised against a 16 amino acid peptide near the amino terminus of human BACE2. The immunogen is located within amino acids 30 - 80 of BACE2.

Isotype: IgG

Application Details

Application Notes: BACE2 can be used for detection of BACE2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 10 μ,g/mL.

Antibody validated: Western Blot in human and mouse samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: BACE2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: BACE2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for BACE2

Target: BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))

Alternative Name: BACE2

Background: BACE2 Antibody: Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at beta-site and at a different site within Abeta. BACE2 locates on chromosome 21q22.3, the so-called 'Down critical region', suggesting that BACE2 and Abeta may also contribute to the pathogenesis of Down syndrome.

Molecular Weight: Predicted: 57 kDa

Observed: 66 kDa

Gene ID: 25825

UniProt: Q9Y5Z0