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BACE2 antibody (C-Term)

BACE2 Reactivity: Human WB, ELISA, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6990329
  • Target See all BACE2 Antibodies
    BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))
    Binding Specificity
    • 15
    • 8
    • 7
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 43
    • 33
    • 12
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 62
    • 2
    • 1
    Rabbit
    Clonality
    • 64
    • 1
    Polyclonal
    Conjugate
    • 29
    • 10
    • 7
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This BACE2 antibody is un-conjugated
    Application
    • 46
    • 30
    • 20
    • 13
    • 13
    • 11
    • 8
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    BACE2 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    BACE2 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human BACE2. The immunogen is located within the last 50 amino acids of BACE2.
    Isotype
    IgG
    Top Product
    Discover our top product BACE2 Primary Antibody
  • Application Notes
    BACE2 antibody can be used for detection of BACE2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2 μ,g/mL.

    Antibody validated: Western Blot in human samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    BACE2 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    BACE2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))
    Alternative Name
    BACE2 (BACE2 Products)
    Synonyms
    AEPLC antibody, ALP56 antibody, ASP1 antibody, ASP21 antibody, BAE2 antibody, CEAP1 antibody, DRAP antibody, 1110059C24Rik antibody, AI850424 antibody, ARP1 antibody, CDA13 antibody, beta-site APP-cleaving enzyme 2 antibody, BACE2 antibody, Bace2 antibody
    Background
    BACE2 Antibody: Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and co-localizes with APP. A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at b-site and at a different site within Abeta. BACE2 locates on chromosome 21q22.3, the so-called 'Down critical region', suggesting that BACE2 and Abeta may also contribute to the pathogenesis of Down syndrome.
    Molecular Weight
    Predicted: 57 kDa

    Observed: 57 kDa
    Gene ID
    25825
    UniProt
    Q9Y5Z0
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