TLR4 antibody (C-Term)

Catalog No. ABIN6990422

The Rabbit Polyclonal anti-TLR4 antibody has been validated for ELISA and IHC (p). It is suitable to detect TLR4 in samples from Human.

Quick Overview for TLR4 antibody (C-Term) (ABIN6990422)

Target: TLR4 (Toll-Like Receptor 4 (TLR4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TLR4 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-TLR4 Antibody

Binding Specificity: C-Term

Specificity: TLR4 antibody is predicted to not cross-react with other TLR protein family members.

Purification: TLR4 Antibody is affinity chromatography purified via peptide column.

Immunogen: TLR4 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human TLR4. The immunogen is located within the last 50 amino acids of TLR4.

Isotype: IgG

Application Details

Application Notes: TLR4 antibody can be used for detection of TLR4 by immunohistochemistry at 5 μ,g/mL.

Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TLR4 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TLR4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for TLR4

Target: TLR4 (Toll-Like Receptor 4 (TLR4))

Alternative Name: TLR4

Background: TLR4 Antibody: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-κ,B. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.

Gene ID: 7099

NCBI Accession: NP_612564

UniProt: O00206

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteins