Cadherin 13 antibody (N-Term)

Catalog No. ABIN6990560

The Rabbit Polyclonal anti-Cadherin 13 antibody is suitable to detect Cadherin 13 in samples from Human and Mouse. It has been validated for WB, ELISA, IF and IHC (p).

Quick Overview for Cadherin 13 antibody (N-Term) (ABIN6990560)

Target: Cadherin 13 (CDH13)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cadherin 13 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Cadherin 13 Antibody

Binding Specificity: AA 150-200, N-Term

Specificity: At least two isoforms of T-cadherin are known to exist.

Purification: T-cadherin Antibody is affinity chromatography purified via peptide column.

Immunogen: T-cadherin antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human T-cadherin. The immunogen is located within amino acids 150 - 200 of T-cadherin.

Isotype: IgG

Application Details

Application Notes: T-cadherin antibody can be used for the detection of T-cadherin by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for for immunohistochemistry starting at 5 μ,g/mL and immunocytochemistry starting at 20 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in mouse samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: T-cadherin Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: T-cadherin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for Cadherin 13

Target: Cadherin 13 (CDH13)

Alternative Name: T-cadherin

Background: T-cadherin Antibody: T-cadherin was initially identified as cadherin-type cell adhesion molecule expressed in various neuronal populations in a temporally and spatially restricted pattern during axon growth. T-cadherin is an atypical member of the cadherin family because it does not possess the typical transmembrane and cytoplasmic domains but is instead anchored to the plasma membrane by glycosylphosphatidylinositol (GPI) linkage. T-cadherin may play a role in malignant tumor development as loss of the chromosome locus containing the T-cadherin gene correlates with the development of a variety of cancers. Recently it has been shown that T-cadherin can act as a receptor for hexameric and high-molecular weight forms of adiponectin, suggesting that T-cadherin may also play a role in metabolic regulation.

Molecular Weight: Predicted: 78, 84 kDa

Observed: 85 kDa

Gene ID: 956

NCBI Accession: NP_001248

UniProt: O75355

Pathways: EGFR Signaling Pathway, Cell-Cell Junction Organization