LKB1 antibody (C-Term)

Catalog No. ABIN6990693

The Rabbit Polyclonal anti-LKB1 antibody (ABIN6990693) specifically detects LKB1 in WB and ELISA. The antibody is reactive with Human and Mouse samples.

Quick Overview for LKB1 antibody (C-Term) (ABIN6990693)

Target: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LKB1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-LKB1 Antibody

Binding Specificity: AA 310-360, C-Term

Purification: LKB1 Antibody is affinity chromatography purified via peptide column.

Immunogen: LKB1 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human LKB1. The immunogen is located within amino acids 310 - 360 of LKB1.

Isotype: IgG

Application Details

Application Notes: LKB1 antibody can be used for detection of LKB1 by Western blot at 1 μ,g/mL. LKB1 often migrates at a higher than expected molecular weight in SDS-PAGE.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: LKB1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: LKB1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for LKB1

Target: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Alternative Name: LKB1

Background: LKB1 Antibody: The LKB1 serine/threonine protein kinase was initially identified as a tumor suppressor gene mutated in human Peutz-Jeghers syndrome (PJS), a condition resulting in the growth of numerous intestinal polyps classed as hamartomas. LKB1 exists as a heterotrimeric complex with two other proteins, Ste20-related adaptor protein (STRAD) and MO25. Together, this complex can phsophorylate and activate the AMP-activate protein kinase (AMPK). Following AMPK activation by LKB1, AMPK then phosphorylates TSC1 and TSC2, key components of the metabolism-regulating TOR signaling pathway, which antagonizes the activation for the TOR pathway. LKB1 has also been shown to play a fundamental role in controlling the spatial orientation of structures required to maintain an ordered, polarized epithelium.

Gene ID: 6794

UniProt: Q15831

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effect