PTK7 antibody (C-Term)

Catalog No. ABIN6990782

The Rabbit Polyclonal anti-PTK7 antibody has been validated for WB, ELISA, IF and IHC (p). It is suitable to detect PTK7 in samples from Human, Mouse and Rat.

Quick Overview for PTK7 antibody (C-Term) (ABIN6990782)

Target: PTK7 (PTK7 Protein tyrosine Kinase 7 (PTK7))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTK7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-PTK7 Antibody

Binding Specificity: AA 880-930, C-Term

Purification: PTK7 Antibody is affinity chromatography purified via peptide column.

Immunogen: PTK7 antibody was raised against a 18 amino acid synthetic peptide from near the carboxy terminus of human PTK7. The immunogen is located within amino acids 880 - 930 of PTK7.

Isotype: IgG

Application Details

Application Notes: PTK7 antibody can be used for detection of PTK7 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human, mouse, and rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PTK7 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: PTK7 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for PTK7

Target: PTK7 (PTK7 Protein tyrosine Kinase 7 (PTK7))

Alternative Name: PTK7

Background: PTK7 Antibody: Protein-tyrosine kinases (PTKs) play important roles in regulating cell proliferation and differentiation during development. One member of the PTK family, PTK7, has been suggested to regulate the planar cell polarity (PCP) pathway in vertebrates and may play a role in neural convergent extension and neural tube closure. PTK7 has also been implicated in the development of cancer. Loss of PTK7 expression was seen in several melanoma cell lines and biopsies. Conversely, high-throughput analysis of acute myeloid leukemia samples showed an increased level of PTK7 expression compared to normal bone marrow and purified CD34+ cells. Multiple isoforms of PTK7 are known to exist.

Gene ID: 5754

UniProt: Q13308

Pathways: RTK Signaling, Tube Formation