ATG10 antibody (C-Term)

Catalog No. ABIN6990826

This Rabbit Polyclonal antibody specifically detects ATG10 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for ATG10 antibody (C-Term) (ABIN6990826)

Target: ATG10 (Autophagy Related 10 (ATG10))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATG10 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-ATG10 Antibody

Binding Specificity: C-Term

Purification: ATG10 Antibody is affinity chromatography purified via peptide column.

Immunogen: ATG10 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human ATG10. The immunogen is located within the last 50 amino acids of ATG10.

Isotype: IgG

Application Details

Application Notes: ATG10 antibody can be used for the detection of ATG10 by Western blot at 0.5 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ATG10 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: ATG10 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for ATG10

Target: ATG10 (Autophagy Related 10 (ATG10))

Alternative Name: ATG10

Background: ATG10 Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. Another member of the autophagy protein family is ATG10, an E2-like enzyme involved in two ubiquitin-like modifications essential for autophagosome formation: ATG12-ATG5 conjugation and the modification of a soluble form of MAP-LC3, a homolog of yeast Apg8, to a membrane-bound form. ATG10 has also been shown to interact with ATG12 in human embryonic kidney cells in the presence of ATG7. Multiple isoforms of ATG10 are known to exist.

Gene ID: 83734

UniProt: Q9H0Y0

Pathways: ER-Nucleus Signaling, Autophagy