LGI3 antibody (AA 390-440)

Catalog No. ABIN6990866

The Rabbit Polyclonal anti-LGI3 antibody has been validated for WB and ELISA. It is suitable to detect LGI3 in samples from Human, Mouse and Rat.

Quick Overview for LGI3 antibody (AA 390-440) (ABIN6990866)

Target: LGI3 (Leucine-Rich Repeat LGI Family, Member 3 (LGI3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LGI3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-LGI3 Antibody

Binding Specificity: AA 390-440

Specificity: Two isoforms of LGI3 are known to exist, this LGI3 antibody will recognize both. This LGI3 antibody is predicted to be specific to LGI3 and not recognize other LGI proteins. The observed higher molecular weight band may represent a post-translationally modified form of LGI3.

Purification: LGI3 Antibody is affinity chromatography purified via peptide column.

Immunogen: LGI3 antibody was raised against a 12 amino acid synthetic peptide from near the center of human LGI3. The immunogen is located within amino acids 390 - 440 of LGI3.

Isotype: IgG

Application Details

Application Notes: LGI3 antibody can be used for the detection of LGI3 by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: LGI3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: LGI3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for LGI3

Target: LGI3 (Leucine-Rich Repeat LGI Family, Member 3 (LGI3))

Alternative Name: LGI3

Background: LGI3 Antibody: The leucine-rich, glioma inactivated gene 3 (LGI3) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI3 have not been found to be associated with ADTLE. LGI3 expression is induced in rat astrocyte cultures by the amyloid beta (Abeta) peptide and accumulated on neuronal plasma membranes of aged monkey brains and co-localized with Abeta.

Gene ID: 203190

UniProt: Q8N145