Calcyphosine 2 antibody (AA 510-560)

Catalog No. ABIN6990892

Product Details anti-Calcyphosine 2 Antibody

Target: Calcyphosine 2 (CAPS2)

Binding Specificity: AA 510-560

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Calcyphosine 2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificity: Multiple isoforms of CAPS2 are known to exist. This CAPS2 antibody is predicted to be specific to CAPS2 and not recognize CAPS1.

Purification: CAPS2 Antibody is affinity chromatography purified via peptide column.

Immunogen: CAPS2 antibody was raised against a 19 amino acid synthetic peptide near the center of the human CAPS2. The immunogen is located within amino acids 510 - 560 of CAPS2.

Isotype: IgG

Application Details

Application Notes: CAPS2 antibody can be used for detection of CAPS2 by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: CAPS2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: CAPS2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for Calcyphosine 2

Target: Calcyphosine 2 (CAPS2)

Alternative Name: CAPS2 (CAPS2 Products)

Synonyms: D630005B03Rik antibody, CAPS2 antibody, calcyphosine 2 antibody, calcyphosphine 2 antibody, CAPS2 antibody, Caps2 antibody, caps2 antibody

Background: CAPS2 Antibody: CAPS2 and the related protein CAPS1 encode novel neural/endocrine-specific cytosolic and peripheral membrane proteins. Both are essential components of the synaptic vesicle priming machinery and are required for the Ca2+-regulated exocytosis of secretory vesicles, CAPS-deficient neurons contain no or very few fusion competent synaptic vesicles, causing a selective impairment of fast phasic transmitter release. Like CAPS1, numerous isoforms of CAPS2 are known to exist. These isoforms show distinct expression patterns in the brain. For example, CAPS2b showed high expression in the developing cerebellum. Furthermore, one version of CAPS2 mRNA that lacks exon 3 is detected in some autistic patients, suggesting that the differential expression pattern of CAPS2 is involved in neuronal development.

Molecular Weight: Predicted: 138, 145 kDa

Observed: 150 kDa

Gene ID: 93664

NCBI Accession: NP_060424

UniProt: Q86UW7