NANOS2 antibody (C-Term)

Catalog No. ABIN6990923

The Rabbit Polyclonal anti-NANOS2 antibody has been validated for ELISA and WB. It is suitable to detect NANOS2 in samples from Human, Mouse and Rat.

Quick Overview for NANOS2 antibody (C-Term) (ABIN6990923)

Target: NANOS2 (Nanos Homolog 2 (NANOS2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NANOS2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-NANOS2 Antibody

Binding Specificity: C-Term

Specificity: This Nanos2 antibody will not cross-react with either Nanos 1 or Nanos3.

Purification: Nanos2 Antibody is affinity chromatography purified via peptide column.

Immunogen: Nanos2 antibody was raised against a 13 amino acid synthetic peptide near the carboxy terminus of the human Nanos2. The immunogen is located within the last 50 amino acids of Nanos2.

Isotype: IgG

Application Details

Application Notes: Nanos2 antibody can be used for detection of Nanos2 by Western blot at 2 to 4 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Nanos2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Nanos2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for NANOS2

Target: NANOS2 (Nanos Homolog 2 (NANOS2))

Alternative Name: Nanos2

Background: Nanos2 Antibody: Nanos is a zinc-finger containing, RNA-binding protein that has been implicated in germ cell development in both invertebrates and vertebrates. In drosophila, Nanos represses apoptosis during development to ensure proper germ-line development. Unlike Nanos1 whose expression in mice is dispensable, the Nanos2 and Nanos3 proteins are required for germ cell development. Nanos2-null primordial germ cells (PGCs) die only in the male gonads and show no defects in females, while Nanos3-null PGCs are lost during the migration stage regardless of sex. Nanos2 and Nanos3 have distinct expression patterns during embryo development, suggesting that these two proteins do not have redundant functions. However, expression of Nanos2 can at least partially replace Nanos3 function in a Nanos3-null background. Nanos3 expression can not rescue Nanos2-null defects.

Gene ID: 339345

UniProt: P60321

Pathways: Retinoic Acid Receptor Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance