NANOS2 antibody (AA 1-138)

Catalog No. ABIN7161035

Product Details anti-NANOS2 Antibody

Target: NANOS2 (Nanos Homolog 2 (NANOS2))

Binding Specificity: AA 1-138

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NANOS2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Nanos homolog 2 protein (1-138AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NANOS2

Target: NANOS2 (Nanos Homolog 2 (NANOS2))

Alternative Name: NANOS2 (NANOS2 Products)

Synonyms: NOS2 antibody, RGD1562436 antibody, nos2 antibody, nanos C2HC-type zinc finger 2 antibody, nanos homolog 2 (Drosophila) antibody, nanos 2 antibody, nanos2 protein antibody, NANOS2 antibody, Nanos2 antibody, nanos2 antibody

Background:

Background: Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state.

Aliases: NANO2_HUMAN antibody, Nanos homolog 2 antibody, Nanos homolog 2 Drosophila antibody, NANOS2 antibody, NOS-2 antibody, NOS2 antibody

UniProt: P60321

Pathways: Retinoic Acid Receptor Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance