NANOS2 antibody (AA 10-90)

Catalog No. ABIN7229900

The Rabbit Polyclonal anti-NANOS2 antibody (ABIN7229900) specifically detects NANOS2 in ELISA and WB. The antibody is reactive with Human and Mouse samples.

Quick Overview for NANOS2 antibody (AA 10-90) (ABIN7229900)

Target: NANOS2 (Nanos Homolog 2 (NANOS2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NANOS2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-NANOS2 Antibody

Binding Specificity: AA 10-90

Purpose: Rabbit Anti-NANO2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of NANO2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human NANO2 protein at AA range: 10-90

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for NANOS2

Target: NANOS2 (Nanos Homolog 2 (NANOS2))

Alternative Name: NANO2

Background: Nanos homolog 2, NOS-2Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity).

Molecular Weight: 15kD

Gene ID: 339345

UniProt: P60321

Pathways: Retinoic Acid Receptor Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance