ACVR1C/ALK7 antibody (N-Term)

Catalog No. ABIN6990976

This Rabbit Polyclonal antibody specifically detects ACVR1C/ALK7 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for ACVR1C/ALK7 antibody (N-Term) (ABIN6990976)

Target: ACVR1C/ALK7 (ACVR1C) (Activin Receptor Type 1C (ACVR1C))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACVR1C/ALK7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-ACVR1C/ALK7 Antibody

Binding Specificity: AA 130-180, N-Term

Specificity: This antibody is predicted to have no cross-reactivity to ACVR1 or ACVR1B.

Purification: ACVR1C Antibody is affinity chromatography purified via peptide column.

Immunogen: ACVR1C antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of the human ACVR1C. The immunogen is located within amino acids 130 - 180 of ACVR1C.

Isotype: IgG

Application Details

Application Notes: ACVR1C antibody can be used for detection of ACVR1C by Western blot at 1 and 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ACVR1C Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: ACVR1C antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for ACVR1C/ALK7

Target: ACVR1C/ALK7 (ACVR1C) (Activin Receptor Type 1C (ACVR1C))

Alternative Name: ACVR1C

Background: ACVR1C Antibody: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. ACVR1C, also known as ALK7, is a type I activin receptor and plays a role in cell differentiation, growth arrest and apoptosis. ACVR1C can mediate signaling by ligans such as Nodal, GDF-1/3, activin B and activin AB, all of which can also signal through the ubiquitous activin type I receptor ACVR1B (also known as ALK4). ACVR1C is a novel marker specifically expressed during the late phase of adipocyte differentiation. ACVR1C is dispensable for mouse embryogenesis, which suggests alternative functions for this receptor in postnatal development and tissue homeostasis. ACVR1C plays an important role in regulating the functional plasticity of pancreatic islets, negatively affecting beta-cell function by mediating the effects of activin B on Ca2+ signaling.

Gene ID: 90

UniProt: Q04771, Q8NER5

Pathways: Negative Regulation of Hormone Secretion, Positive Regulation of Endopeptidase Activity