SPRED2 antibody (AA 140-190)

Catalog No. ABIN6990997

This Rabbit Polyclonal antibody specifically detects SPRED2 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for SPRED2 antibody (AA 140-190) (ABIN6990997)

Target: SPRED2 (Sprouty-Related, EVH1 Domain Containing 2 (SPRED2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPRED2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SPRED2 Antibody

Binding Specificity: AA 140-190

Specificity: This Spred2 antibody is predicted to have no cross-reactivity to Spred1 or Spred3.

Purification: Spred2 Antibody is affinity chromatography purified via peptide column.

Immunogen: Spred2 antibody was raised against a 13 amino acid synthetic peptide near the center of the human Spred2. The immunogen is located within amino acids 140 - 190 of Spred2.

Isotype: IgG

Application Details

Application Notes: Spred2 antibody can be used for detection of Spred2 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Spred2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Spred2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for SPRED2

Target: SPRED2 (Sprouty-Related, EVH1 Domain Containing 2 (SPRED2))

Alternative Name: Spred2

Background: Spred2 Antibody: Spred2 is a member of the Sprouty family, a group of proteins that act as negative regulators during development. Like Spred1, Spred2 acts by suppressing the phosphorylation and activation of Raf. The Spred proteins have also been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis. Further studies have shown that expression levels of Spred1 and Spred2 proteins are inversely correlated with the incidence of tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting that these proteins could be useful as prognostic factors and therapeutic targets in HCC. At least two isoforms of Spred2 are known to exist.

Gene ID: 200734

NCBI Accession: NP_861449

UniProt: Q7Z698