DISP2 antibody (C-Term)

Catalog No. ABIN6991010

Product Details anti-DISP2 Antibody

Target: DISP2 (Dispatched Homolog 2 (DISP2))

Binding Specificity: AA 1210-1260, C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DISP2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Purification: Disp2 Antibody is affinity chromatography purified via peptide column.

Immunogen: Disp2 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human Disp2. The immunogen is located within amino acids 1210 - 1260 of Disp2.

Isotype: IgG

Application Details

Application Notes: Disp2 antibody can be used for the detection of Disp2 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Disp2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Disp2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for DISP2

Target: DISP2 (Dispatched Homolog 2 (DISP2))

Alternative Name: Disp2 (DISP2 Products)

Synonyms: DISP2 antibody, DISPB antibody, HsT16908 antibody, AI840597 antibody, B230210L08Rik antibody, DispB antibody, mKIAA1742 antibody, dispatched RND transporter family member 2 antibody, dispatched RND tramsporter family member 2 antibody, dispatched homolog 2 (Drosophila) antibody, DISP2 antibody, Disp2 antibody

Background: Disp2 Antibody: Disp2 is the second of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the Disp proteins have been implicated in these pathways. Recently, it has been shown that Disp2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased Disp2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by Disp2 mutants. At least two isoforms of Disp2 are known to exist. This Disp2 antibody is predicted to not cross-react with Disp1 or Disp3.

Gene ID: 85455

UniProt: A7MBM2

Pathways: Hedgehog Signaling