RHBDD3 antibody (AA 170-220)

Catalog No. ABIN6991242

The Rabbit Polyclonal anti-RHBDD3 antibody (ABIN6991242) specifically detects RHBDD3 in WB, ELISA and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for RHBDD3 antibody (AA 170-220) (ABIN6991242)

Target: RHBDD3 (Rhomboid Domain Containing 3 (RHBDD3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RHBDD3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-RHBDD3 Antibody

Binding Specificity: AA 170-220

Purification: RHBDD3 Antibody is affinity chromatography purified via peptide column.

Immunogen: RHBDD3 antibody was raised against a 13 amino acid synthetic peptide from near the center of human RHBDD3. The immunogen is located within amino acids 170 - 220 of RHBDD3.

Isotype: IgG

Application Details

Application Notes: RHBDD3 antibody can be used for detection of RHBDD3 by Western blot at 1 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: RHBDD3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: RHBDD3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for RHBDD3

Target: RHBDD3 (Rhomboid Domain Containing 3 (RHBDD3))

Alternative Name: RHBDD3

Background: RHBDD3 Antibody: The Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development. RHBDD3 was initially identified as a novel pituitary tumor apoptosis gene (PTAG) whose expression was reduced in certain pituitary adenomas. Overexpression of RHBDD3 in AtT20 cells showed an increase in apoptotic activity and caspase activation in response to bromocriptine, and apoptosis-inducing dopamine D2 analog, suggesting that reactivation of RHBDD3 in tumors may be a therapeutically useful tool. Later experiments also showed that RHBDD3 expression is also reduced in several primary colorectal tumors, indicating that loss of RHBDD3 contributes to a blunted apoptotic response and probably predisposes cells towards malignant transformation.

Gene ID: 25807

NCBI Accession: NP_036397

UniProt: Q9Y3P4