Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

IDH1 antibody (C-Term)

This anti-IDH1 antibody is a Rabbit Polyclonal antibody detecting IDH1 in WB and ELISA. Suitable for Human, Mouse and Rat.
Catalog No. ABIN6991362

Quick Overview for IDH1 antibody (C-Term) (ABIN6991362)

Target

See all IDH1 Antibodies
IDH1 (Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1))

Reactivity

  • 133
  • 68
  • 47
  • 8
  • 7
  • 7
  • 5
  • 5
  • 5
  • 4
  • 4
  • 4
  • 3
  • 2
  • 2
  • 1
  • 1
Human, Mouse, Rat

Host

  • 97
  • 57
  • 3
  • 1
Rabbit

Clonality

  • 88
  • 70
Polyclonal

Conjugate

  • 100
  • 11
  • 10
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This IDH1 antibody is un-conjugated

Application

  • 111
  • 63
  • 36
  • 34
  • 33
  • 30
  • 28
  • 15
  • 13
  • 9
  • 5
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA
  • Binding Specificity

    • 15
    • 14
    • 12
    • 10
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Purification

    IDH1 Antibody is affinity chromatography purified via peptide column.

    Immunogen

    IDH1 antibody was raised against a 13 amino acid synthetic peptide near the carboxy terminus of human IDH1. The immunogen is located within the last 50 amino acids of IDH1.

    Isotype

    IgG
  • Application Notes

    IDH1 antibody can be used for detection of IDH1 by Western blot at 1 - 2 μ,g/mL.

    Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    IDH1 Antibody is supplied in PBS containing 0.02 % sodium azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C,4 °C

    Storage Comment

    IDH1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target

    IDH1 (Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1))

    Alternative Name

    IDH1

    Background

    IDH1 Antibody: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Two NADP(+)-dependent isocitrate dehydrogenases have been found as homodimer: IDH1 is predominantly cytosolic and peroxisomal and IDH2 is mitochondrial. The presence of IDH1 in peroxisomes suggests it may play a role in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic IDH1 serves a significant role in cytoplasmic NADPH production. Defects in IDH1 are involved in the development of glioma.

    Gene ID

    3417

    NCBI Accession

    NP_005887

    UniProt

    O75874

    Pathways

    Warburg Effect
You are here:
Chat with us!