DYRK2 antibody (C-Term)

Catalog No. ABIN6991515

This anti-DYRK2 antibody is a Rabbit Polyclonal antibody detecting DYRK2 in WB, ELISA, IF and ICC. Suitable for Human.

Quick Overview for DYRK2 antibody (C-Term) (ABIN6991515)

Target: DYRK2 (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 2 (DYRK2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DYRK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-DYRK2 Antibody

Binding Specificity: AA 520-570, C-Term

Specificity: Two isoforms of DYRK2 are known to exist, this antibody will recognize both isoforms. DYRK2 antibody will not cross-react with other DYRK family members.

Purification: DYRK2 Antibody is affinity chromatography purified via peptide column.

Immunogen: DYRK2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human DYRK2. The immunogen is located within amino acids 520 - 570 of DYRK2.

Isotype: IgG

Application Details

Application Notes: DYRK2 antibody can be used for detection of DYRK2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: DYRK2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: DYRK2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for DYRK2

Target: DYRK2 (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 2 (DYRK2))

Alternative Name: DYRK2

Background: DYRK2 Antibody: DYRK2 is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family that is thought to be involved in cellular proliferation and apoptosis. Under normal conditions, nuclear but not cytoplasmic DYRK2 is ubiquitinated by MDM2, leading to its constitutive degradation. However, upon exposure to genotoxic stress, ATM phosphorylates DYRK2, leading to its dissociation from MDM2 and its phosphorylation of p53, thereby inducing apoptosis. Recent evidence also suggests that DYRK2 may serve as a scaffold that facilitates assembly of an E3 ubiquitin ligase.

Gene ID: 8445

NCBI Accession: NP_006473

UniProt: Q92630

Pathways: Regulation of Carbohydrate Metabolic Process