Strumpellin antibody (C-Term)

Catalog No. ABIN6991586

Product Details anti-Strumpellin Antibody

Target: Strumpellin (WASHC5) (WASH Complex Subunit 5 (WASHC5))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Strumpellin antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: Multiple isoforms of Strumpellin are known to exist.

Purification: Strumpellin Antibody is affinity chromatography purified via peptide column.

Immunogen: Strumpellin antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human Strumpellin. The immunogen is located within the last 50 amino acids of Strumpellin.

Isotype: IgG

Application Details

Application Notes: Strumpellin antibody can be used for detection of Strumpellin by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Strumpellin Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Strumpellin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for Strumpellin

Target: Strumpellin (WASHC5) (WASH Complex Subunit 5 (WASHC5))

Alternative Name: Strumpellin (WASHC5 Products)

Synonyms: SPG8 antibody, AL022848 antibody, C76463 antibody, Kiaa0196 antibody, mKIAA0196 antibody, strumpellin antibody, WASH complex subunit 5 antibody, WASHC5 antibody, washc5 antibody, Washc5 antibody

Background: Strumpellin Antibody: Strumpellin is a ubiquitously expressed, multi-transmembrane and spectrin-repeat-containing protein. It is named for Strumpell disease, a progressive upper-motor neurodegenerative disease termed hereditary spastic paraplegia (HSP). The Strumpellin gene maps to the eighth HSP locus (SPG8) on chromosome 8p24.13. Three families liked to this locus have mutations in the Strumpellin gene, rescue studies of zebrafish with decreased Strumpellin expression with Strumpellin mRNA containing these mutations showed impaired normal function of this protein. Recent studies suggest that Strumpellin may also be involved in protein aggregation diseases.

Gene ID: 9897

NCBI Accession: NP_055661

UniProt: Q12768