SARM1 antibody (N-Term)

Catalog No. ABIN6991709

The Rabbit Polyclonal anti-SARM1 antibody is suitable to detect SARM1 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and IF.

Quick Overview for SARM1 antibody (N-Term) (ABIN6991709)

Target: SARM1 (Sterile alpha and TIR Motif Containing 1 (SARM1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SARM1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-SARM1 Antibody

Binding Specificity: AA 30-80, N-Term

Specificity: At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. SARM antibody recognize the longest isoform.

Purification: SARM Antibody is affinity chromatography purified via peptide column.

Immunogen: SARM antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human SARM. The immunogen is located within amino acids 30 - 80 of SARM.

Isotype: IgG

Application Details

Application Notes: SARM antibody can be used for detection of SARM by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: SARM Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: SARM antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for SARM1

Target: SARM1 (Sterile alpha and TIR Motif Containing 1 (SARM1))

Alternative Name: SARM

Background: SARM Antibody: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SARM (SAM and ARM-containing protein), along with other molecules such as TIRP, TRIF, TIRAP, and MyD88, is thought to serve as an adaptor protein for the TLRs that allows for the activation of downstream kinases and NF-κ,B, and ultimately the expression of proteins involved in host defense. While SARM has not been conclusively shown to associate directly with TLRs, the presence of a Toll-interleukin-1 (TIR) domain in SARM is consistent with a role as a signaling molecule.

Gene ID: 23098

NCBI Accession: NP_055892

UniProt: Q6SZW1

Pathways: TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades