APBA1 antibody (N-Term)

Catalog No. ABIN6991712

The Rabbit Polyclonal anti-APBA1 antibody is suitable to detect APBA1 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and IF.

Quick Overview for APBA1 antibody (N-Term) (ABIN6991712)

Target: APBA1 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APBA1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-APBA1 Antibody

Binding Specificity: AA 90-140, N-Term

Specificity: At least two alternatively spliced isoforms are known to exist, this antibody will detect both isoforms. This antibody is predicted to not cross-react with other APBA proteins.

Purification: APBA1 Antibody is affinity chromatography purified via peptide column.

Immunogen: APBA1 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human APBA1. The immunogen is located within amino acids 90 - 140 of APBA1.

Isotype: IgG

Application Details

Application Notes: APBA1 antibody can be used for detection of APBA1 by Western blot at 0.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: APBA1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: APBA1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for APBA1

Target: APBA1 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1))

Alternative Name: APBA1

Background: APBA1 Antibody: The Amyloid beta 4 (A4) precursor protein-binding family A member 1 (APBA1) is a member of the X11 protein family and a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). APBA1 stabilizes APP and inhibits production of proteolytic APP fragments including the Aβ, peptide that is deposited in the brains of Alzheimer's disease patients. It is thought to be involved in signal transduction processes and is a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. APBA1 can also bind to CASK, a multidomain scaffolding protein involved in brain development and synapse formation.

Molecular Weight: Predicted: 92 kDa

Observed: 92 kDa

Gene ID: 320

NCBI Accession: NP_001154

UniProt: Q02410

Pathways: Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport