CISD2 antibody (AA 40-90)

Catalog No. ABIN6991848

Product Details anti-CISD2 Antibody

Target: CISD2 (CDGSH Iron Sulfur Domain 2 (CISD2))

Binding Specificity: AA 40-90

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CISD2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: CISD2 Antibody is affinity chromatography purified via peptide column.

Immunogen: CISD2 antibody was raised against a 15 amino acid peptide near the center of human CISD2. The immunogen is located within amino acids 40 - 90 of CISD2.

Isotype: IgG

Application Details

Application Notes: CISD2 antibody was raised against a 15 amino acid peptide near the center of human CISD2.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: CISD2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: CISD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for CISD2

Target: CISD2 (CDGSH Iron Sulfur Domain 2 (CISD2))

Alternative Name: CISD2 (CISD2 Products)

Background: CISD2 Antibody: Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype.

Molecular Weight: Predicted: 15 kDa

Observed: 15 kDa

Gene ID: 493856

NCBI Accession: NP_001008389

UniProt: Q8N5K1

Pathways: Activation of Innate immune Response